This book tackles the most difficult and profound open questions about life and its origins from an information-based perspective.

The COVID-19 pandemic has raised a host of ethical challenges, but key among these has been the possibility that health care systems might need to ration scarce critical care resources. Rationing p...

Fred Dretske asserts that the conscious or phenomenal experiences associated with our perceptual states—e.g. the qualitative or subjective features involved in visual or auditory states—are identical to properties that things have according to our representations of them. This is Dretske's version of the currently popular representational theory of consciousness . After explicating the core of Dretske's representational thesis, I offer two criticisms. I suggest that Dretske's view fails to apply to a broad range of mental phenomena that have rather distinctive (...) subjective or qualitative features. I also suggest that Dretske's view, in identifying conscious experiences with features of our perceptual states, casts its aim too low. It deflates further than it should and, in consequence, fails to capture what are arguably some of the most important phenomena associated with our conscious lives. (shrink)

Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type mice at the (...) same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:News from the President’s Council on BioethicsF. Daniel Davis (bio) and Diane M. Gianelli (bio)As most readers of this column already know, the President's Council on Bioethics went through a major transition during the past year when Leon Kass—in October 2005—handed the chairman's gavel over to Georgetown University's Edmund Pellegrino. Dr. Kass has remained on the Council as a member.1When the gavel change took place, the Council's phone (...) started ringing. Everyone wanted to know the same thing: What topics would the Council take up this term? Dr. Pellegrino's answer was always the same: The Council's agenda would be established through a consultative process with the members themselves and with an eye to those problems and controversies in bioethics to which we, as a body, can make a contribution.Taking its cue from the list of potential topics suggested by members, the Council—over the course of the next several meetings—listened to experts on such topics as children and bioethics (with a focus on children in clinical research), organ transplantation, and that oft-cited-but-hard-to-define concept, "human dignity."The latter topic entered the arena of discussion because it is a concept that is cited frequently in the bioethics literature, and it is also one that has figured prominently in Council discussions and documents. Although the concept is widely invoked, there is no universal understanding of what it means, and it is not easy to encapsulate into a one-size-fits-all definition. Indeed, some critics maintain that appeals to human dignity are fig leaves used to camouflage unconvincing arguments. So between December 2005 and April 2006, the Council devoted several sessions to various perspectives on "human dignity: its meaning, its foundations, and its relevance to bioethics." After hearing from James Childress, Patricia Churchland, Daniel Sulmasy, and Paul Weithman2 on the topic, the Council decided to issue a volume of approximately 20 essays, some by Council members and others by scholars from a variety of relevant disciplines.3 The volume is expected to encompass a broad array of opinion on the topic of human dignity and is scheduled to be published next spring."Children" were also the focus of several sessions during the past year. The Council's last report addressed care giving for the elderly.4 After it was issued, several members suggested it was time to focus on the youngest members of [End Page 375] society. The challenge, of course, was to find a topic that was both timely and relevant—and one about which the Council was uniquely qualified to make a contribution. A number of experts in a variety of related fields testified before the Council about possible issues it could explore: newborn screening for genetic disorders; decision-making standards for those who lack capacity; ethical issues in neonatal and pediatric intensive care; pharmacology and psychiatric disorders in children; and children and clinical research. In addition, a number of groups and individuals involved in related topics met with staff to discuss their interests and concerns.This exploratory engagement with facets of the broad topic of children and bioethics led the Council to focus, more narrowly, on a cluster of issues concerning newborn screening for genetic disorders—a topic on which it is likely that the Council will issue a white paper, possibly by next summer. The stimulus for this particular focus has been the American College of Medical Genetics's recommendation that all newborns in the U.S. be screened for a panel of 29 disorders.5 Currently, each state decides for its residents which conditions are subject to mandated screening, so it is possible to get early diagnoses of treatable disorders in one geographical area but not in another. Proponents of screening find the federal approach to mandated screening more equitable. Potential ethical problems, however, exist with the proposal. Some want to ensure that newborns are screened only for treatable conditions on grounds that it would be too burdensome to discover one is carrying the gene for a late-onset disease that cannot be prevented. Others want to make sure that insurance coverage for individuals and their families is... (shrink)

An innovative, multifaceted approach to scientific experiments as designed by and shaped through interaction with the modeling process The role of scientific modeling in mediation between theories and phenomena is a critical topic within the philosophy of science, touching on issues from climate modeling to synthetic models in biology, high energy particle physics, and cognitive sciences. Offering a radically new conception of the role of data in the scientific modeling process as well as a new awareness of the problematic aspects (...) of data, this cutting-edge volume offers a multifaceted view on experiments as designed and shaped in interaction with the modeling process. Contributors address such issues as the construction of models in conjunction with scientific experimentation; the status of measurement and the function of experiment in the identification of relevant parameters; how the phenomena under study are reconceived when accounted for by a model; and the interplay between experimenting, modeling, and simulation when results do not mesh. Highlighting the mediating role of models and the model-dependence of data measurement, this volume proposes a normative and conceptual innovation in scientific modeling--that the phenomena to be investigated and modeled must not be precisely identified at the start but specified during the course of the interactions arising between experimental and modeling activities. Contributors: Nancy D. Cartwright, U of California, San Diego; Anthony Chemero, U of Cincinnati; Ronald N. Giere, U of Minnesota; Jenann Ismael, U of Arizona; Tarja Knuuttila, U of South Carolina; Andrea Loettgers, U of Bern, Switzerland; Deborah Mayo, Virginia Tech; Joseph Rouse, Wesleyan U; Paul Teller, U of California, Davis; Michael Weisberg, U of Pennsylvania; Eric Winsberg, U of South Florida. (shrink)

In his middle and later periods one of Wittgenstein’s concerns was perception. This is, of course, precisely what one would expect given his obvious interest then in the notion of experience and in the language we employ to describe and express our experiences. However, the passage which has attracted most attention is the discussion in sec. XI of part II of Philosophical Investigations which is concerned with “seeing as”, or “aspect seeing”. In this paper the examples that Wittgenstein uses are (...) examined, and some puzzles about them raised. It is suggested that Wittgenstein’s aim is to discredit some supposedly mistaken accounts of what ‘seeing as’ is. These mistaken accounts are supposed to made by Gestalt psychologists such as Kohler, and traditional sense-datum theorists. It is further argued that Wittgenstein’s criticisms are not uniformly cogent. It is, though, conceded that this rich and original passage contains far more than the elements investigated here, so much more needs to be scrutinised. (shrink)

What kind of thing are we? Paul Snowdon's answer is that we are animals, of a sort. This view--'animalism'--may seem obvious but on the whole philosophers have rejected it. Snowdon argues that animalism is a defensible way of thinking about ourselves. Its rejection rests on the tendency when doing philosophy to mistake fantasy for reality.

The Pasadena game invented by Nover and Hájek raises a number of challenges for decision theory. The basic problem is how the game should be evaluated: it has no expectation and hence no well-defined value. Easwaran has shown that the Pasadena game does have a weak expectation, raising the possibility that we can eliminate the value gap by requiring agents to value gambles at their weak expectations. In this paper, I first prove a negative result: there are gambles like the (...) Pasadena game that do not even have a weak expectation. Hence, problematic value gaps remain even if decision theory is extended to take in weak expectations. There is a further challenge: the existence of a ‘value gap’ in the Pasadena game seems to make decision theory inapplicable in a number of cases where the right choice is obvious. The positive contribution of the paper is a theory of ‘relative utilities’, an extension of decision theory that lets us make comparative judgements even among gambles that have no well-defined value. (shrink)

Fish proposes that we need to elucidate what 'disjunctivism' stands for, and he also proposes that it stands for the rejection of a principle about the nature of experience that he calls the decisiveness principle. The present paper argues that his first proposal is reasonable, but then argues, in Section II, that his positive suggestion does not draw the line between disjunctivism and non-disjunctivism in the right place. In Section III, it is argued that disjunctivism is a thesis about the (...) special nature of perceptual experience, and the thesis as elucidated here is then distinguished from and related to certain other ideas about perception, namely, direct realism and also McDowell's epistemological disjunctivism. (shrink)

Originally published by Rand McNally & Company in 1969, this volume provides a discussion of the Gilded Age, the decades between the end of the Civil War and the closing of the Spanish-American War. Many aspects of this period are examined, including the transition from a rural-agrarian federation to an industrial, urban nation-state. An intensive study of ideas, this volume fulfills the need for an informative and highly readable work of the intellectual and cultural developments in an important era of (...) American History. (shrink)

My topic is personal identity, or rather, our identity. There is general, but not, of course, unanimous, agreement that it is wrong to give an account of what is involved in, and essential to, our persistence over time which requires the existence of immaterial entities, but, it seems to me, there is no consensus about how, within, what might be called this naturalistic framework, we should best procede. This lack of consensus, no doubt, reflects the difficulty, which must strike anyone (...) who has considered the issue, of achieving, just in one's own thinking, a reflective equilibrium. The theory of personal identity, I feel, provides a curious contrast. On the one side, it seems highly important to know what sort of thing we are, but, on the other, it is hard to find any answer which has a ‘solid’ feel. (shrink)

Explanations of cognitive processes provided by traditional artificial intelligence were based on the notion of the knowledge level. This perspective has been challenged by new AI that proposes an approach based on embodied systems that interact with the real‐world. We demonstrate that these two views can be unified. Our argument is based on the assumption that knowledge level explanations can be defined in the context of Bayesian theory while the goals of new AI are captured by using a well established (...) robot based model of learning and problem solving, called Distributed Adaptive Control (DAC). In our analysis we consider random foraging and we prove that minor modifications of the DAC architecture renders a model that is equivalent to a Bayesian analysis of this task. Subsequently, we compare this enhanced, “rational,” model to its “non‐rational” predecessor and a further control condition using both simulated and real robots, in a variety of environments. Our results show that the changes made to the DAC architecture, in order to unify the perspectives of old and new AI, also lead to a significant improvement in random foraging. (shrink)

Explanations of cognitive processes provided by traditional artificial intelligence were based on the notion of the knowledge level. This perspective has been challenged by new AI that proposes an approach based on embodied systems that interact with the real‐world. We demonstrate that these two views can be unified. Our argument is based on the assumption that knowledge level explanations can be defined in the context of Bayesian theory while the goals of new AI are captured by using a well established (...) robot based model of learning and problem solving, called Distributed Adaptive Control (DAC). In our analysis we consider random foraging and we prove that minor modifications of the DAC architecture renders a model that is equivalent to a Bayesian analysis of this task. Subsequently, we compare this enhanced, “rational,” model to its “non‐rational” predecessor and a further control condition using both simulated and real robots, in a variety of environments. Our results show that the changes made to the DAC architecture, in order to unify the perspectives of old and new AI, also lead to a significant improvement in random foraging. (shrink)

There are a number of concepts of common-sense morality, what one must do, what one ought to do, the supererogatory, the minimum that duty allows, the morally optional and the morally indifferent, that philosophers have been hard-pressed to represent in an integrated conceptual framework. Indeed, many philosophers have despaired at the attempt and concluded that only a fragment of these concepts belong to that fundamental sphere of morality that is the central focus of the ethicist. For example, the traditional scheme, (...) with its triad of the obligatory, the forbidden and the permissible, pigeonholes all actions into three mutually exclusive and exhaustive classes: those which are obligatory, those which are forbidden and those which are optional. Hence, at best, it can represent exactly two of the six aforementioned concepts. For from the standpoint of this scheme, what one must do and what one ought to do can't be distinguished and hence they can't both be represented. Although the morally optional can be represented, the supererogatory, one of its subclasses, cannot be represented. Furthermore, the morally indifferent, another subclass of the optional--one which is obviously disjoint from the supererogatory--cannot be represented. Finally, the minimum that duty allows finds no distinctive place in the traditional scheme. Thus, on the face of it, the traditional scheme is radically incomplete. ;I present, motivate and defend a new conceptual scheme for common-sense morality in which these concepts are represented and systematically integrated. An intuitively motivated semantic framework underpinning this conceptual scheme is also presented. Such a scheme, along with the associated semantic framework, is motivated by reflecting on the supererogationist's objections to utilitarianism and to the traditional scheme. But in addition, a new integrated network of linguistic motivations for this conceptual scheme is uncovered, one which is completely independent of supererogationistic considerations. Hence, these two separate sources of evidence for the centrality of this new scheme to our pre-theoretic thinking corroborate one another--thus jointly boosting the evidence beyond the mere sum of their separate evidential values. (shrink)

This article provides a critical examination of a controversial issue that has theoretical and practical importance to a broad range of academic disciplines: Are religious experiences localized within the brain? Research into the neuroscience of religious experiences is reviewed and conceptual and methodological challenges accompanying the neurotheology project of localizing religious experiences within the brain are discussed. An alternative theory to current reductive and mechanistic explanations of observed mind–brain correlations is proposed — a mediation theory of cerebral action — that (...) has the potential for addressing what Chalmers called the “hard problem” of consciousness. (shrink)

In his famous Wager, Blaise Pascal offers the reader an argument that it is rational to strive to believe in God. Philosophical debates about this classic argument have continued until our own times. This volume provides a comprehensive examination of Pascal's Wager, including its theological framework, its place in the history of philosophy, and its importance to contemporary decision theory. The volume starts with a valuable primer on infinity and decision theory for students and non-specialists. A sequence of chapters then (...) examines topics including the Wager's underlying theology, its influence on later philosophical figures, and contemporary analyses of the Wager including Alan Hájek's challenge to its validity, the many gods objection, and the ethics of belief. The final five chapters explore various ways in which the Wager has inspired contemporary decision theory, including questions related to infinite utility, imprecise probabilities, and infinitesimals. (shrink)

Professor Donaldson in his book Corporations and Morality has attempted to use a social contract theory to develop moral principles for regulating corporate conduct. I argue in this paper that his attempt fails in large measure because what he refers to as a social contract theory is, in fact, a weak functionalist theory which provides no independent basis for evaluating business corporations. I further argue that given the nature of a morality based on contract and the nature of the modern (...) corporation, it is highly unlikely that any plausible contract theory of business ethics can be developed. (shrink)

The authors argue that the time is ripe for national and corporate leaders to move consciously towards the development of global ethics. This papers presents a model of global ethics, a rationale for the development of global ethics, and the implications of the model for research and practice.